Carbonyl Chemistry

The Morita-Bayliss-Hillman Reaction - nucleophilic addition-aldol-elimination

  Baylis-Hillman: "The Baylis-Hillman Reaction — A Novel Carbon-Carbon Bond-Forming Reaction," Basavaiah, D.; Rao, P. D.; Hyma, R. S. Tetrahedron 1996, 52, 8001-62. "The Catalyzed α-Hydroxyalkylation and α-Aminoalkylation of Activated Olefins (the Morita-Baylis-Hillman Reaction)," Ciganek, E. Org. React. 1997, 51, 201-350."New Strategies for the Development of an Asymmetric Version of the Baylis-Hillman Reaction," Langer, P. Ang. Chem IE 2000, 39, 3049-52. "Synthesis of Cyclic Compounds from the Baylis-Hillman Adducts," Kim, J. N.; Lee, K. Y. Curr. Org. Chem. 2002, 6, 627-45. Basavaiah, D.; Rao, A. J.; Satyanarayana, T. "Recent Advances in the Baylis-Hillman Reaction and Applications," Chem. Rev. 2003, 103, 811-91.

Rafel, S.; Leahy, J.W. J. Org. Chem., 1997, 62, 1521


 

Intramolecular Morita-Bayliss-Hillman Reaction

  Vinylogous Bayliss-Hilman: Krische J. Am. Chem. Soc. 2002, 124, 2402 (Rousch 2404)


 

  Synthesis of Spinosyn A Nucleus: Mergott, D. J.; Frank. S. A.; Rousch, W. R. Org. Lett. 2002, 4, 3157


 

Activation of α-Nucleophilic Addition

Trost, B.M. J. Am. Chem. Soc. 1997, 119, 7595