Total synthesis of Abscisic Acid:
| Reference: | Constantino, M. G.; Losco, P.; Castellano, E. E. J. Org. Chem. 1989, 54, 681. DOI |
| Reactions: | Robinson annulation, ketoester • KetoEster enolate+Enone • Cyclohexenone • Ketone → Ketal • Epoxide → Allyl-OH • Ketone → EnolEther • Epoxidation, peracid • CompOx-Alkene/Enoate+Peracid • Reformatsky • Enal+Enolate • CarboxEster enolate+Enal • Lactone-6 • EnoateEster → Allyl-OH • Allyl-OH → Enal • Dehydroacetoxylation → EnoateEster • Ketal → Ketone • |
| Reagents: | Methyl vinyl ketone • Acetoacetate • Acetoacetate • Orthoformate • ZnCl2 • Glycol • H2SO4 • H2SO4 • AlH4-Li+ • MnO2 • Oxalic acid • Hydroxide, sodium • Allyl-Br • Zn° • Perbenzoic acid, 3-chloro • |