Total synthesis of Acoradiene:
| Reference: | Ficini, J.; Revial, G.; Genet, J. P. Tetrahedron Lett. 1981, 22, 629, 633. DOI |
| Reactions: | Wittig-methyl → Diene • EnAmine → Ketone • Allyl-OR → Allyl-H • Ynamine+CarboxEster • Spiro(54) • Mechanism • Ketone → EnolEther • Lactone-6 • O-H → O-P(O)X2 • |
| Reagents: | PPh3=CH2 • Malonate • TsOH • Acetic acid • Me-Li • P(O)(OR)2Cl • Li°/NH3 • Ynamine • |