Total synthesis of Allethrolone (Buchi) New:
| Reference: | Büchi, G.; Minster, D.; Young, J. C. F. J. Am. Chem. Soc. 1971, 93, 4319. DOI |
| Reactions: | Li-Dichloromethyl+Ketone • Aldol-Acid → Aldol • Cyclopentenone • EnolEther → Ketone • Epoxidation via halohydrin • Ketal → Vinyl-OR • Ketone → Ketal(Me) • Epoxide → Allyl-OH • |
| Reagents: | Me2C(OMe)2 • TsOH • TsOH • LiCHCl2 • HCl, H2O • Hydroxide, barium • |