Total synthesis of Argentilactone:
| Reference: | Carretero, J. J.; Ghosez, L Tetrahedron Lett. 1988, 29, 2059. DOI |
| Reactions: | Orthoester → CarboxEster • Wittig-alkyl → Ene-cis • Li-Sulfone+Epoxide • Dehydrosulfonylation → EneLactone • Diol-1,2 → Epoxide • Ketal → Diol-1,2 • O-H → O-SO2Ar • CompNu-O-H/O-H+RSO2X • Lactone-6 • |
| Reagents: | PPh3=CH-Alkyl • HCl, MeOH • NaOMe • Epoxide • LiCHR-Sulfonyl • LiCHR-Sulfonyl • TsOH • NEt3 • TsCl, Py • |