Total synthesis of Capsaicin:
| Reference: | Kaga, H.; Miura, M.; Orito, K. J. Org. Chem. 1989, 54, 3477–3478. DOI |
| Reactions: | CarboxAcid → CarboxCl • Alkyl-X → Alkyl-PRn • Wittig-alkyl → Ene-cis • Alkene isomerization-EZ • CarboxAcid → CarboxAmide • Reductive amination, HCO2H • Leuckart • |
| Reagents: | Formate, ammonium • PPh3 • PPh3=CH-Alkyl • KOtBu • SOCl2 • |