Total Syntheses

Reaction scheme for total synthesis of the natural product Civetone
Total synthesis of Civetone:
Reference:Furstner, A.; Seidel, G, J. Orgmet. Chem. 2000, 606, 75
Reactions:Alkyne metathesis • Cycloheptadecane • Alkyne → Ene-cis (Lindlar) • Alkyl-OH → Ketone • Mg-Alkyl+Aldehyde • Aldehyde+Mg-R •
Reagents:Cr2O7·2PyH (PDC) • W≡CtBu(OtBu)3 • Mo(CO)6 • H2, Pd •