Total synthesis of Giffonin H New:
| Reference: | Park, S.; Kim, S.-H.; Jeong, J. H.; Shin, D. Org. Chem. Front. 2019, 6, 704. DOI |
| Reactions: | O-H → O-MOM (phenol) • Aryl-Br → Aryl-OR • Julia-Kocienski coupling • Li-Sulfone+Aldehyde • CarboxEster → Alkyl-OH • Alkyl-OH → Aldehyde • Si-Alkynyl+Aldehyde • Aldehyde+Si-R • O-MOM → O-H • Paracyclophane • Ether-9+ • |
| Reagents: | Chloromethyl ether • NEtiPr2 • CuI • Carbonate, cesium • HCl • DBU • AlH4-Li+ • DMSO, (COCl)2 (Swern) • NEt3 • TASF • HCl, H2O • LiCHR-Sulfonyl • |