Total synthesis of Hemibrevetoxin B (partial) (Mori):
| Reference: | Mori, Y.; Yaegashi, K.; Furukawa, H. J. Am. Chem. Soc. 1997, 119, 4557. DOI |
| Reactions: | O-SiEt3 → O-H • O-SiEt3 → O-H • Li-Epoxide+Alkyl-X • Alkyl-X+Li-R • Li/H → Li-Epoxide • Li-Epoxide+Aldehyde • Aldehyde+Li-R • Li/H → Li-Epoxide • Ether-6 • Epoxide+M-OR • Bicyclo(440)-oxa • Ether-6 • |
| Reagents: | HMPA (solvent) • LiCHR-Sulfonyl • TsOH • LiCHR-Sulfonyl • Epoxide • BF3·OEt2 • |