Total synthesis of Linalyl oxide:
| Reference: | Rychnovsky, S. D.; Bartlett, P. A. J. Am. Chem. Soc. 1981, 103, 3963-3964. DOI |
| Reactions: | Li-Vinyl+Aldehyde • Li-Me+Ketone • Ketone+Li-Alkyl • Li-Me+Ketone • Ketone+Li-Alkyl • Dehydrohalogenation → Allyl-OR • Claisen-EnolEther • Iodoetherification • Ether-5 • Mechanism • |
| Reagents: | Vinyl-Li • Me-Li • Me-Li • I2 • KOtBu • I2 • KOtBu • |