Total synthesis of Methylenomycin B (Tius):
| Reference: | Tius, M. A.; Astrab, D. P.; Fauq, A. H.; Ousset, J.-B.; Trehan, S. J. Am. Chem. Soc. 1986, 108, 3438-3442. DOI |
| Reactions: | Nazarov • Cyclopentenone • Li-Allenyl/Propargyl+Ketone • Enone+Li-R • Allene synthesis • |
| Reagents: | Methyl vinyl ketone • Allenyl-Li • Acetic anhydride, trifluoro • Lutidine • |