Total synthesis of Vitamin B3:
| Reference: | Stiller, B. T.; Harris, S. A.; Finkelstein, J.; Keresztesy, J. C.; Folkers, K. J. Am. Chem. Soc. 1940, 112, 1785–1790. DOI |
| Reactions: | Aldol-K → Aldol • Aldehyde enolate+Aldehyde • Aldehyde → Cyanohydrin • Cyanide+Aldehyde • Nitrile → CarboxAcid • Lactone-5 • Lactone → CarboxAmide • CarboxEster → CarboxAcid • |
| Reagents: | Formaldehyde • Carbonate, potassium • Cyanide, potassium • Chloride, calcium • Hydroxide, sodium • |