Total synthesis of Patulolide C:
| Reference: | Risi, R. M.; Burke, S. D. Org. Lett. 2012, 14, 1180–1182. DOI |
| Reactions: | Hydroacetoxylation Alkyne • Hydroformylation • Wittig-carboxymethyl → EnoateEster • Lactone-9+ • Wittig (intram) • O-H → O-C(O)R • |
| Reagents: | Rh(cod)Cl • Acetic acid • Rh(CO)2acac • CO, H2 • Lipase • PPh3=C=C=O • |