Total synthesis of Pipecolic Acid:
| Reference: | Carlson, E. C.; Rathbone, L. K.; Yang, H.; Collett, N. D.; Carter, R. G. J. Org. Chem. 2008, 73, 5155. DOI |
| Reactions: | Olefin cross metathesis • ConjAdd Amine (asym) • Amine-6 • Alkyl-OH → Ketone • N-Cbz → N-H • Aldehyde+Mg-R • Mg-Alkyl+Aldehyde • |
| Reagents: | Crotonaldehyde • Grubbs II • Chiral catalyst (amine) • Me-MgBr • Dess-Martin • H2, Pd • |