Total synthesis of Ryanodine:
| Reference: | Xu, C.; Han, A.; Virgil, S.C.; Reisman, S. E. ACS Cent. Sci. 2017, 3, 278-282. DOI |
| Reactions: | O-BOM → O-H • O-H → O-C(O)R • Diol-1,2 → BoronateEster • Enone → Allyl-OH • CompRed-Ketone/CarboxEster+M-H • Hydrogenation Diene • Epoxidation, V • Radical cyclization(Alkyl) • Boronate ester → Diol-1,2 • |
| Reagents: | B(OH)2Me • BH4-Li+ • NaH • Bifluoride, potassium • H2, Pt • Hydroperoxide, tbutyl - V • LiDBB • |