Total synthesis of Hydroxyviocristin New:
| Reference: | Kuttruff, C. A.; Zipse, H,; Trauner, D. Angew. Chem. Int. Ed. 2011, 50, 1402-1405. DOI |
| Reactions: | Anthraquinone synthesis • CarboxEster enolate+Quinone • ConjAdd Enolate • Decarboxylation β-keto acid • O-Me → O-H (phenol) • CarboxAcid → CarboxAmide • Peptide • N-Cbz → N-H • Lactam-6 • Pd/B-Alkyl+Aryl-X • Olefin cross metathesis • Aryl-H → Aryl-Cl • B-Allyl+Imine • Aldol-Acid → Enone • Vilsmeier formylation • Aryl-H → Aryl-CHO • Friedel-Crafts Acylation • Diels-Alder-inverse, EnAmine • Spiro(55)-aza • |
| Reagents: | NaH • AlCl3 • Allyl-SnR3 • PdCl2 • PPh3 • NCS • Allyl-BR2 • Vilsmeier reagent • H2, Pd • HCl • SOCl2 • NH3 • Carbodiimide • HOBT • NEtiPr2 • Grubbs II • O2 • |